Anti-Apo A-1 IgG is an independent predictor of major cardiovascular events in rheumatoid arthritis (RA).Positivity for anti-Apo A-1 IgG is associated with higher levels of IL-8, oxidized LDL, and MMP-9.Anti-Apo A-1 IgG induces pro-inflammatory responses in macrophages. The gene discussed is CXCL8; the disease is rheumatoid arthritis.