IL-6 positively correlates with cardiovascular risk predictors (FRS, SCORE) and biomarkers (NT-proBNP, HS-CRP).IL-6 levels are higher in RA patients compared to controls and correlate with disease activity (DAS-28).IL-6 could be considered a biomarker for subclinical cardiovascular risk in RA patients. The gene discussed is CRP; the disease is rheumatoid arthritis.