SLE patients show higher levels of ADMA, hs-CRP, and MCP-1 than controls, which are significantly correlated with increased carotid intima-media thickness (IMT).MCP-1 A−2518G polymorphism, particularly the G/G genotype, is associated with a higher risk of carotid atherosclerosis.ADMA and MCP-1 are strong independent predictors of increased IMT. This evidence concerns the gene CCL2 and systemic lupus erythematosus.