NPPB and rheumatoid arthritis: For instance, Aiewruengsurat et al. (17) found only weak correlations between cardiac biomarkers—such as hsTropT and NT-proBNP—and cardiac structure and function in rheumatoid arthritis (RA) patients, while Ajeganova et al. (18) demonstrated that RF or Anti-CCP positivity combined with high inflammatory markers like C-Reactive Protien (CRP) and Erythrocyte Sedimentation Rate (ESR) increased CVD risk, particularly in RA patients with early disease onset.