CRP and intestinal disorder: In the multivariate analyses, the remaining four variables emerged as independent risk factors for failure to achieve steroid-free remission at Week 26: active intestinal fistula at baseline (odds ratio [OR] = 8.345, 95% confidence interval [95% CI] 2.469–28.206, P = 0.001), bio-exposed (OR = 3.646, 95%CI 1.925–6.906, P < 0.001), CDAI > 220 points (OR = 8.528, 95% CI 4.135–17.591, P < 0.001) and CRP > 10 mg/L (OR = 1.969, 95%CI 1.014–3.821, P = 0.045).