F8 and hemophilia A: Hemophilia A (OMIM: 306700), a rare X-linked recessive inherited hemorrhagic disorder with a prevalence rate of approximately 1 in 5,000 live male births, is characterized by the deficiency of the coagulation factor VIII (FVIII) due to a wide spectrum of pathogenic variants in the F8 gene (Gitschier et al., 1984).