Furthermore, in cisplatin‐resistant ovarian cancer cells, tetrahydroxycurcumin causes cell‐cycle arrest in G2/M by an increase in apoptosis and phosphorylation of p53 after a caspase 3‐mediated degradation of p53 and poly (ADP‐ribose) polymerase‐1 (PARP) (Terlikowska et al. 2014). This evidence concerns the gene CASP3 and ovarian carcinoma.