AKT1 and neoplasm: Figure 2 demonstrates that curcumin, the parent compound of tetrahydroxycurcumin, and particularly curcumin nanoparticle, improves chemotherapy sensitivity, induces mitochondrial apoptosis, blocks pro‐survival AKT signaling, and recovers p53 pharmacologic activity to prevent tumor growth and metastasis (Kao et al. 2020).