TERT and glioblastoma: Conversely, glioblastomas are defined by a wild-type IDH status, alongside hallmark alterations such as Epidermal Growth Factor Receptor (EGFR) amplification, Telomerase Reverse Transcriptase (TERT) promoter mutations, and chromosomal abnormalities, including the gain of chromosome 7 and loss of chromosome 10 [4].