SPMIP4 and central nervous system cancer: LINGO1 [25,114,115] and C7orf31 are linked to poor survival, with roles in adhesion signaling and genomic stability still under investigation [114,116] Other genes, such as ZNF217, FABP7, and GSTM5, exhibit inverse methylation-expression patterns, indicating that epigenetic silencing of these oncogenic or metabolic regulators may also shape glioma behaviour [108] Similarly, TUBB6, DTX1, and integrin subunits (ITGA3, ITGA5, ITGB1) support cytoskeletal remodeling and motility through actin dynamics and focal adhesion pathways [117,118].