TP53 and biliary tract neoplasm: In this study, adavosertib induced S or G2/M phase arrest in p53 MT GIST cells (Fig. 2A,B), consistent with previous reports that elucidated its role in inducing S/G2/M arrest in p53 MT biliary tract cancer, gastric cancer, GIST, and anaplastic thyroid carcinoma (ATC) [14,30,49,52].