Furthermore, adavosertib treatment led to a significant increase in caspase-3/7 activity and a higher percentage of cells in the sub-G1 phase, as well as both early and late apoptosis in p53 MT GIST cells (GIST882 and GIST-T1) (Figs. 2 and 3). Here, TP53 is linked to gastrointestinal stromal tumor.