EGF and urinary bladder carcinoma: For example, Xie et al. [34] reported that Wnt7A enhances EGF-induced migration in oral squamous cell carcinoma via activation of the PI3K/AKT/MMP9 pathway, while Thi et al. [35] showed that CD46 promotes bladder cancer metastasis by regulating MMP9 through activation of p38 MAPK, PI3K, and AKT pathways.