Analysis of TCGA and Gene Expression Omnibus (GEO) databases revealed that CDK5RAP3 expression is generally low in GC tissues and that its reduced expression is closely associated with malignant features—including larger tumor size, deeper infiltration and advanced Tumor–Node–Metastasis (TNM) staging—as well as significantly lower patient survival rates [21]. Here, CDK5RAP3 is linked to neoplasm.