Lin et al. found that UFM1 suppresses GC cell invasion and metastasis by decreasing 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression, thereby inhibiting the AKT/glycogen synthase kinase-3 beta (GSK3β) signaling pathway and reducing epithelial-mesenchymal transition (EMT) activity [5]. This evidence concerns the gene UFM1 and gastric cancer.