Additionally, the tRNA fragment tRF-GluCTC-0005 found in PDAC-derived exosomes can enhance the stability of WD repeat-containing protein 1 (WDR1) mRNA and activate hepatic stellate cells, thereby mediating the infiltration of myeloid-derived suppressor cells, promoting the formation of PMN, and facilitating liver metastasis of PC [53]. The gene discussed is WDR1; the disease is pachyonychia congenita.