Lymphocyte activation gene-3 (LAG-3), T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and T cell immunoreceptor with Ig and ITIM domains (TIGIT) are highly expressed in exhausted T cells within the TME and contribute to immune dysfunction [49,51,52]. This evidence concerns the gene HAVCR2 and immune system disorder.