LOXL2 and head and neck squamous cell carcinoma: Additionally, lysyl oxidase-like 2 (LOXL2)-rich hypoxia-derived exosomes deliver LOXL2 to non-hypoxic HNSCC cells, triggering EMT, enhancing invasion, and promoting pre-metastatic niche formation via the focal adhesion kinase (FAK)/Src pathway [95].