TGFB1 and neoplasm: miRNAs from tumor-derived exosomes (miR-192 and miR-215) can target Caveolin-1 and suppress TGF-β/mothers against decapentaplegic homolog (SMAD) signaling, leading to the differentiation of normal fibroblasts into CAFs, while miR-21 does this by targeting YOD1 [94].