Tregs, characterized by the expression of Forkhead Box P3 (FOXP3), accumulate within the tumor bed and secrete immunosuppressive cytokines such as transforming growth factor beta (TGF-β) and interleukin-10 (IL-10), thereby inhibiting effective cytotoxic T lymphocyte (CTL) responses [5,16]. This evidence concerns the gene TGFB1 and neoplasm.