LGALS3BP and neoplasm: Conversely, in liver tissues, which serve as a centralhub for drug metabolism and clearance, both DM4 and S-Met-DM4 were consistently detected across all ADC-treated groups(Figure G, right panel).Interestingly, at 72 h post-treatment, nearly all DM4 that reachedthe metastatic lung tissue resulted to be metabolized into S-Met-DM4; meanwhile, the liver exhibited relatively higherlevels of DM4 than the targeted lung tissues in both LGALS3BP-positiveand -negative tumor-bearing mice.