Although such honeycombing is generally indicative of a chronic fibrotic process rather than acute vasculitic changes, this interpretation aligns with previous reports showing that MPO-ANCA-positive patients frequently develop interstitial pneumonia and pulmonary fibrosis, whereas PR3-ANCA-positive patients more commonly present with pulmonary nodules, cavitary lesions, and ear-nose-throat involvement. This evidence concerns the gene MPO and pulmonary fibrosis.