IL33 and inflammatory skin disease: In the context of inflammatory skin diseases, oxidative stress can disrupt the skin's hydrolipid barrier, damage keratinocyte DNA, oxidize lipids in the stratum corneum, and induce the production of pro-inflammatory cytokines—interleukin-1β (IL-1β) and interleukin 33 (IL-33)—in the dermis, promoting inflammation and exacerbating the disease (120).