Using RNA-Seq analysis of AML cells derived from the mouse model, they narrowed their focus to two genes, GRB2-associated–binding protein 2 (Gab2) and p21-activated kinase 1 (Pak1) (Figure 1), which were also identified as highly essential in AML based on the DepMap analysis (24). Here, PAK1 is linked to acute myeloid leukemia.