Some common driver mutations in AML occur in the genes DNA methyltransferase 3 α (DNMT3A), nucleophosmin 1 (NPM1), fms-like tyrosine kinase 3 (FLT3), ten-eleven translocation methylcytosine dioxygenase 2 (TET2), TP53, and isocitrate dehydrogenase (IDH) (10–15). The gene discussed is NPM1; the disease is acute myeloid leukemia.