Consistently, S100A8+IBA1+ macrophages were significantly increased in liver samples from patients with MASH compared with healthy controls (Figure 6, C and D), reinforcing the relevance of these findings to human disease and implicating S100A8+ macrophages as a link between adipocyte death and the pathogenesis of MASLD in patients. This evidence concerns the gene S100A8 and metabolic dysfunction-associated steatotic liver disease.