Regarding the specific role of S100A8+ macrophages in liver diseases, Liu et al. reported that S100A8 promotes liver fibrosis in a carbon tetrachloride–induced mouse model by activating the TLR4/NF-κB signaling pathway in macrophages and inducing NLRP3 inflammasome-dependent pyroptosis (28). Here, TLR4 is linked to Hepatic fibrosis.