S100A8 and metabolic dysfunction-associated steatotic liver disease: Experimental models have shown that neutrophil-derived S100A8 contributes to disease progression in MASLD and other conditions (20–22), but conclusive evidence for the in vivo functions of S100A8 has been limited due to lack of S100a8-KO mice (global S100a8-KO mice are embryonic lethal) (23).