CD274 and non-small cell lung carcinoma: Similarly, in lung tissue samples obtained from patients with NSCLC and a mouse NSCLC model, the authors identified tumor cells expressing high levels of TGF-β1 and CCL2, as well as Toe-Macs expressing NLRP3, IL-1β, TGF-β1, CCL2, IL-6, and PD-L1.