In conclusion, Liu et al. (13) provided evidence that Toe-Macs are induced by DME-derived TGF-β1 or CCL2 and constitute a common subset of pathogenic macrophages that could be selectively targeted as a single population, owing to their shared susceptibility to TET3 reduction in MASH, NSCLC, and endometriosis. The gene discussed is TET3; the disease is endometriosis.