In addition to its well-established contribution to hypertension, overactivation of the AngII/AT1R axis is one of the most significant modifiable risk factors for stroke, contributing to vasoconstriction, increased sympathetic tone, oxidative stress, inflammation, disruption of the BBB, and endothelial dysfunction, key processes in stroke pathogenesis (176). The gene discussed is AGTR1; the disease is endothelial dysfunction.