In a model of polymicrobial sepsis–induced lung inflammation, a single 10 μg/kg dose of semaglutide treatment suppressed lung Tnf, Il6, and Il1b expression and attenuated lung neutrophil elastase staining 24 hours after infection, an effect absent in Glp1rWnt1–/– mice with inactivation of neuronal GLP-1Rs (22). The gene discussed is TNF; the disease is Sepsis.