In contrast, neutrophil-specific deletion (via S100a8-Cre) of Uba1 recapitulated a VEXAS-like syndrome, including neutrophilia, macrocytosis, vacuolated myeloid precursors, splenomegaly, skin (but not cartilage) inflammation, and elevated systemic cytokine levels (IL-1β, IL-6, and TNF-α). The gene discussed is UBA1; the disease is VEXAS syndrome.