In line with this, the synaptic‐enriched M5 (Glycolysis) module, which is strongly correlated with disease pathology and includes tau (MAPT) as a hub protein, was also low in Subtype 3 compared to other AD‐like subtypes, suggesting that the lower immunoassay tau levels may be associated with the overall reduction of neuronal proteins in this module. Here, MAPT is linked to Alzheimer disease.