APOE and Cognitive impairment: Within this cluster, M4, the Ubiquitination module, showed strong correlations with CSF Aβ, t‐tau, and p‐tau181, as well as APOE genetic risk (quantified by the number of APOE ε2, APOE ε3, and APOE ε4 alleles, scaled by risk) and cognitive impairment (assessed via MoCA score).