ZNRF3 and central nervous system cancer: In platinum‐resistant ovarian cancer, Rmrp promotes mRNA translation by recruiting DEAD‐Box Helicase 3 X‐Linked to enrich PHGDH mRNA.[65] In temozolomide‐resistant glioma, Rmrp interacts with insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) and ZNRF3 mRNA to inhibit IGF2BP3‐mediated ZNRF3 mRNA stability.[61] Rmrp affects metabolic processes through a competitive endogenous RNA mechanism.