PFKFB3 catalyzes the production of fructose‐2,6‐bisphosphate, which activates phosphofructokinase‐1, thereby promoting glycolysis.[41] PFKFB3 induces a pro‐inflammatory phenotype in macrophages during sepsis;[41] however, its role in immune tolerance in AMs after SII remains unclear. The gene discussed is PFKFB3; the disease is Sepsis.