Herein, a T cell membrane (TCM)‐coated biomimetic magnesium carbonate (MgCO3)/Fe‐CD hybrid nanozyme system loaded with the Pyruvate kinase M2 (PKM2) activator TEPP‐46 (TFMP) is developed, designed to simultaneously induce mitochondrial metabolic reprogramming in both T cells and tumor cells following radiotherapy (RT). Here, PKM is linked to neoplasm.