Consequently, NFκB targets BCL-xL and COX2 were upregulated in p21<sup>T145D</sup>- and AKT<sup>T308D,S473D</sup> CRC cells in vitro and in a chorioallantoic membrane (CAM) model, supporting their role as downstream effectors of cytoplasmic p21. The gene discussed is AKT1; the disease is colorectal carcinoma.