HDODs also occupy a larger proportion of mixed phenotype acute leukemias (MPALs) (Figure S2A), express higher levels of HOXA10 (Figure S2B), and patients harboring HDODs have poorer OS (HR = 2.495, 95% CI: 1.147–5.426, p = 0.0394) in comparison to patients with LDODs (Figure S2C). Here, HOXA10 is linked to acute leukemia.