TDP‐43 aggregates are prevalent in more than 90% of ALS patients, ∼50% of frontotemporal dementia (FTD) patients, up to 60% of AD cases, as well as a more recently recognized dementia called limbic‐predominance age‐related TDP‐43 encephalopathy (LATE) [2, 3, 4]. The gene discussed is TARDBP; the disease is Alzheimer disease.