In addition, unbiased mass spectrometry (MS)‐based phospho‐proteomics has revealed multiple phosphorylation sites in the C‐terminal LCR as well as more N‐terminal regions in a small cohort of ALS and FTD patients [39, 40] (Figure 1, dark red lines), expanding the view of TDP‐43's phosphorylation landscape. This evidence concerns the gene TARDBP and frontotemporal dementia.