This is in line with the recent cryo‐EM structures of brain‐derived TDP‐43 aggregates, which revealed that the protease‐resistant core of the extracted TDP‐43 aggregates has a different amyloid‐like fold in ALS and FTD‐TDP type B cases than in FTD‐TDP type A cases [12, 13]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.