The variability of the clinical presentation underscores the need for thorough evaluation against uncovered underlying conditions, such as some PAD [HIES (STAT3‐DN‐HIES, DOCK8 deficiency, Comel‐Netherton Syndrome), ERBIN deficiency, JAK1 AD GOF, STAT5b GOF, and STAT6 GOF], especially when the disease is severe, atypical, or associated with other atopic conditions (e.g., asthma, eczema, FA).47, 90, 93, 103, 104, 105, 106, 107, 108. Here, STAT3 is linked to peripheral arterial disease.