The variability of the clinical presentation underscores the need for thorough evaluation against uncovered underlying conditions, such as some PAD [HIES (STAT3‐DN‐HIES, DOCK8 deficiency, Comel‐Netherton Syndrome), ERBIN deficiency, JAK1 AD GOF, STAT5b GOF, and STAT6 GOF], especially when the disease is severe, atypical, or associated with other atopic conditions (e.g., asthma, eczema, FA).47, 90, 93, 103, 104, 105, 106, 107, 108. The gene discussed is STAT5B; the disease is peripheral arterial disease.