Furthermore, ectodermal dysplasia, defined as structural abnormalities of the skin and its appendages (hair, nails, teeth), is commonly seen in certain syndromic IEIs, such as HIES or ectodermal dysplasia‐immunodeficiency syndromes [e.g., IKBKG (NEMO) deficiency].74 This evidence concerns the gene IKBKG and ectodermal dysplasia syndrome.