grouped PAD according to the dominating pattern of clinical symptoms as follows: (1) hyper‐IgE syndromes (HIES); (2) Omenn syndrome (OS); (3) Wiskott‐Aldrich syndrome (WAS) and WAS‐like conditions; (4) immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) and IPEX‐like conditions; (5) Caspase recruitment domain (CARD) proteins – B‐cell CLL/lymphoma 10 (BCL10) – MALT1 paracaspase (MALT1) (CBM) – opathies; (6) miscellaneous IEI with predominant allergic manifestations. The gene discussed is BCL10; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.