TIGIT expressed on B cells interacts with CD155+ follicular helper T (TFH) cells to suppress TFH cell proliferation and reduced TIGIT expression on B cells causes CCR6+ TFH cell expansion in patients with multiple sclerosis, demonstrating a negative feedback loop between TIGIT+ B cells and TFH cell in multiple sclerosis pathogenesis146. The gene discussed is PVR; the disease is multiple sclerosis.