IL1B and COVID-19: This leads to the upregulation of pro-inflammatory cytokines such as Interleukin-6 (IL-6), TNF-α, and IL-1β and contributing to the cytokine storm, a hyperinflammatory state characterized by the uncontrolled systemic release of cytokines [29] and pulmonary pathology seen in critical COVID-19 patients [28,30].