In this multicentric cohort study involving Chinese PCa patients receiving ADT, we newly identified four germline SNPs: rs36119043 in AKR1D1, rs151155810 in HSD17B12, rs71179009 in SULT2B1, and rs28609134 in SRD5A3 that were significantly associated with increased risk of ADT failure. The gene discussed is HSD17B12; the disease is posterior cortical atrophy.