eQTL analyses further revealed that rs28609134, as well as putative causal SNPs in LD with rs36119043 and rs71179009, were probably associated with dysregulation of SRD5A3, AKR1D1, and SULT2B1 expression, suggesting the functional relevance of these risk loci in androgen metabolism and PCa treatment response. This evidence concerns the gene AKR1D1 and posterior cortical atrophy.