SPP1 and cancer: Consistent with our observations in the mouse model, we identified the same pattern across these human cancer types: CXCL9+ macrophages with broadly pro-inflammatory and interferon (IFN) gamma-activated gene expression profiles (figure 3H) exhibited the lowest NRF2-imprinted TAM scores; anti-inflammatory SPP1+ macrophages displayed the highest scores, and double-positive cells showed intermediate scores.