To generalize our observation that the dichotomous Cxcl9+ and Spp1+ TAM spectrum reflects an NRF2 activation gradient, we reanalyzed publicly available scRNA-seq data from human colorectal and pancreatic cancers as well as glioblastoma (figure 3G).24 The gene discussed is CXCL9; the disease is familial pancreatic carcinoma.