Top gene expression markers show that these clusters represent both unique cell types including fibroblasts (cluster 7: Col12a1, Dpt, Pdgfra), myeloid cells (cluster 6: H2-Eb1, H2-Aa, CD74), and endothelial cells (cluster 9: Cdh5, Plvap), as well as signatures that may represent separate tumor transcriptional programs such as hypoxia (cluster 2: Hspa1b, Hmox1, Ndrg1) and interferon response (cluster 8: Irf7, Ifi47;onlinesupplemental figure 3J ,  table 1). Here, HSPA1B is linked to neoplasm.