Next, by collating (from CRISPR-Cas9 screens20–42) cancer genes that modulate tumor-cell killing by cytotoxic CD8+ T cells or responses to ICIs (Figures S1B–S1E; Table S3), we identified 519 resister (Figure S1B) and 877 sensitizer (Figure S1D) genes (whose knockout promoted resistance and sensitivity, respectively, each with support from ≥2 screens). This evidence concerns the gene CD8A and neoplasm.