We also evaluated the melanoma-intrinsic (i.e., T cell-absent) apoptotic priming states by measuring mitochondrial cytochrome c release in response to BCL-2 homology 3 domain (BH3)-mimetic peptide treatments of the M486 AR1 and AR2 sublines, ± double- or triple-gene overexpression, versus the isogenic P line (Figures 6F and S6G). Here, CYCS is linked to melanoma.