TERT and undifferentiated carcinoma: Since MAPK activation in BRAF p.V600E- or RAS-mutated tumors increases TERT transcription, BRAF p.V600E or RAS co-mutation with TERT has been strongly associated with advanced disease and poor outcome, even in aggressive tumors, such as high grade non-anaplastic (12) and anaplastic carcinoma (38).