The mechanism through which this occurs was unraveled in 2013 when two seminal articles showed that a high proportion of melanomas have mutually exclusive mutations at two hotspots in the TERT promoter (positions −124, C228T and −146, C250T) that create novel binding sites for ETS (erythroblast transformation specific) family transcription factors, thereby promoting TERT transcription (165, 166). This evidence concerns the gene TERT and melanoma.