TERT and papillary carcinoma: In particular, the THYT1 signature, a combination of TERT promoter mutation, duplication of Chr5p (harboring the TERT genomic locus) and duplication of Chr1q (a chromosomal site specifically associated with poor prognosis in papillary carcinoma (11), any of these three alterations), has been proposed as a marker for metastatic spread and poor outcome in papillary carcinoma (15).