Other top DEGs in vehicle-treated MS iMGLs included genes previously described to be involved in MS pathology, such as GPR183 (also known as EBI2) and FPR1 [66–68], or those directly linked to MS microglia, such as CAT, SEMA4A, HLA-DRA, HLA-DPA1, GPNMB, SLC11A1, CD74, MSR1, ALOX5, HSPA1A, C1QA and FCGR2B [20, 21, 25, 27, 69–72]. Here, GPNMB is linked to myeloid sarcoma.