The strong interactions between COL6A3+ TAFs and ICAM1+ MDMs via ligand-receptor binding of TGFB3-TGFBR1/TGFBR2 and CSF1-CSF1R induce their reprogramming into an immunosuppressive phenotype and migration, thereby promoting GBM progression. Here, TGFB3 is linked to glioblastoma.