CLOCK and colorectal carcinoma: Taken together, these data suggest that in right-sided CRC, NONO promotes malignancy by simultaneously perturbing intrinsic clock output, which destabilizes proliferative control, and maintaining a receptor repertoire that heightens responsiveness to pro-tumor microenvironmental signals—thus tightly coupling circadian dysregulation with the molding of a malignant niche(Fig. 8).