We further highlighted the top 5 genes for each cell subpopulation: Tregs (IL7R, FYB1, SARAF, SLC2A3, FXYD5), fibroblasts (COL1A1, COL1A2, COL3A1, IGFBP5, CXCL14), tumor cells (KRT8, PHGR1, KRT18, TFF3, ELF3), and CD8 T cells (GZMB, GZMA, CCL4, NKG7, CCL5) (sFig. 1C). This evidence concerns the gene IGFBP5 and neoplasm.