Additionally, a significant association was identified between the recessive model of the rs2278163 DLX3 and rs12154178 ESR1 polymorphisms and mild and moderate fluorosis (p = 0.02, OR = 0.25, 95% CI: 0.07–0.88 and p = 0.034, OR = 0.31, 95% CI: 0.10–0.95, respectively). Here, ESR1 is linked to dental fluorosis.