The secondary outcomes include HbA1c, and homoeostasis model-insulin resistance index (HOMA-IR), an indicator of insulin resistance, will be calculated via formula as follows: [fasting glucose (nmol/L) × fasting insulin (mU/mL)/22.5], fasting blood glucose, 2-h postprandial blood glucose, BMI, waist circumference(WC), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and systolic and diastolic blood pressure.The primary and secondary outcomes will be reevaluated at the end of 12 weeks. This evidence concerns the gene INS and Insulin resistance.