Analysis of 1,783 participants (688 with depression) revealed that depressed patients exhibited a higher ALT/AST ratio (0.9 vs. 0.8; P < 0.001) with lower BUN (5.4 vs. 6.5 mmol/L; P < 0.001) and BUN/Cr ratio (19.4 vs. 21.2; P < 0.001). This evidence concerns the gene GPT and depressive symptom measurement.