The downregulation of their expression is associated with better prognosis in several cancers, such as XK in ACC, CNNM4 in READ, KEL in CESC, CNNM3 in KIRC, as well as CNNM2 in LGG and KIRC (Fig. 1B). The gene discussed is CNNM3; the disease is adrenal cortex carcinoma.