Furthermore, in most cancers, MHS were significantly positively correlated with the expression of chemokine genes such as CXCL12, CCL16, CCL14, CCL21, CCL19, CXCL14, CX3CL1, and CCL28, and negatively correlated with CCL3, CXCL9, CXCL11, and CXCL10 (P < 0.05) (Fig. 9D). The gene discussed is CXCL12; the disease is cancer.