The mutation rates of different MHGs varied widely across cancer tissues, with ANK3 having the highest mutation rate (47%), followed by KEL (18%), TRPM7 (16%), KCNA1 (13%), CNNM2 (9%), CNNM1 (9%), TFAP2B (9%), CNNM4 (9%), XK (7%), and EDN3 (5%). Here, TFAP2B is linked to cancer.