Furthermore, in most cancers, MHS were significantly positively correlated with the expression of chemokine genes such as CXCL12, CCL16, CCL14, CCL21, CCL19, CXCL14, CX3CL1, and CCL28, and negatively correlated with CCL3, CXCL9, CXCL11, and CXCL10 (P < 0.05) (Fig. 9D). Here, CCL21 is linked to cancer.