CASP3 and acute lymphoblastic leukemia: Furthermore, analysis of caspase activation (in Reh and PreB697 lines) demonstrated that re-expression of SLC22A15 was associated with rapid induction of caspases 3/7 (Fig. 3c) in the absence of alteration in the underlying rate of proliferation (Fig. 3d), suggesting that re-expression of SLC22A15 resulted in induction of cell death and thus functions to inhibit ALL cell survival in all ALL cytogenetic subgroups tested.