To study the impact of the mutations investigated so far on a model that could better recapitulate the molecular background of FGFR1-mutated brain tumors we used the human oligodendroglioma cell line (HOG) and we applied CRISPR/Cas9 to generate isogenic FGFR1-mutant HOG cell lines (Fig. 6A). This evidence concerns the gene FGFR1 and brain neoplasm.