By examining tumor grade of hotspot-positive brain tumor types, we found that multiple FGFR1 alterations are found in similar rates in both low-grade (grades 1–2) and high-grade (grades 3–4) cases, with a higher number of double-mutant cases identified in low-grade types (Fig. 1B; Table 3). This evidence concerns the gene FGFR1 and brain neoplasm.