FGFR1 and low grade glioma: Additional FGFR1 missense mutations in cis have been reported in low-grade gliomas (LGGs) developed by ECCL individuals classified as midline pilocytic astrocytomas (Bennett et al, 2016; Valera et al, 2018), providing additional evidence for a driver role of multiple FGFR1 mutations in LGGs/LGGNTs.