FGFR1 and central nervous system cancer: On the other hand, somatic alterations such as FGFR1 gene amplification, duplication of the tyrosine kinase domain, gene fusions and hotspot single-nucleotide variants (SNV) have been found enriched in many types of solid tumors, including lung squamous cell carcinoma, urothelial carcinoma and glioma (Helsten et al, 2016).