PSEN1 and Alzheimer disease: Violin plot revealed increased Cxcl16 expression levels in APP/PS1 “Disease-Associated Microglia” cell cluster (DAM, Wilcoxon test, p < 0.05) compared to WT (Fig. 2a), suggesting Cxcl16 as a signature marker of AD-related microglia states in APP/PS1 brain tissue.