The AD pathology-dependent microglial Cxcl16 expression is further supported by the IHC analysis of APP/PS1 dentate gyrus, which revealed the presence of Cxcl16 signal (white) in the proximity of Iba1+ microglia cells (red) around Aβ plaques (green) (Fig. 2c). The gene discussed is APP; the disease is Alzheimer disease.