RNASE1 and triple-A syndrome: To evaluate the impact of extracellular nucleic acid degradation on vascular remodeling and inflammation in AAA, aortic cross-sections from PBS-, RNase A-, and DNase I-treated AngII mice were stained for smooth muscle actin (SMA) and CD68 (Fig. 3A–C), or Masson’s trichrome (Fig. 3D–F), and manually scored 0–3 for area covered by SMA+ cells, frequency of CD68+ cell infiltration, and CD68+ SMA+ co-localization.