To assess whether systemic nucleic acid degradation may also modulate aneurysm progression in the EPPE model, C57BL/6J mice were similarly treated daily with RNase A, DNase I, or PBS from day 5 to day 13 following aneurysm induction, as shown in the experimental schematic (Supplementary Fig. 2D). This evidence concerns the gene RNASE1 and aneurysm.