The CLN7 interactome includes the core HOPS subunit VPS18, but also VPS26A/B, VPS29 and VPS35 proteins are increased in BD iNPC, all of which are components of the retromer complex which recycles proteins from endosomes to the Golgi and where gene mutations have previously been associated to neurodegenerative disease [44]. The gene discussed is VPS35; the disease is Behcet disease.