S100A4 and neurodegenerative disease: The top-ranking transcripts ranked by Manhattan distance included CHCHD2 (also known as MNRR1) and Clusterin (CLU) upregulation, with downregulation of FABP3 and S100A4, modulation, all having previously been associated with neurodegenerative disease (Fig. 3D, Tables 2 and 3); [30–33].