Consistent with the proteomic nuclear phenotype in BD there was also an enrichment of nuclear proteins, particularly those that interact with RNA, including RNA helicases (DDX23, DHX29, DHX30, and DHX57), integrator complex proteins (INTS3, INTS4) and RNA stability (CDC73, GTPB1, GTPB4). The gene discussed is DHX30; the disease is Behcet disease.