Lower levels of colocalization were seen between PAD-exposed tau inclusions and tau phosphorylated at S396/S404 (PHF1 antibody; fraction of TNT1 overlapping with PHF1 = 0.216 ±0.076) in AD-tau neurons, and PHF1 reactivity was found in all conditions (Fig. 4E-H). This evidence concerns the gene PHF1 and Alzheimer disease.