CGAS and obesity due to melanocortin 4 receptor deficiency: Although mitochondrial damage and mtDNA were reported as upstream inducers of the cGAS-STING pathway in mouse models of obesity-related diabetes [66, 67], these observations do not contradict our results and reported downstream mtDNA release in Coxiella burnetii infection acting as positive feedback for cGAS-STING signaling amplification [63].