According to the literature, in HPV16+/p53WT HNSCC, where wild type p53 is inactivated by the HPV oncogene, E6, high ALDH7A1 correlated with poor prognosis [29], indicating that p53 functional status is an important factor influencing the association between ALDH7A1 expression and patient prognosis. This evidence concerns the gene ALDH7A1 and head and neck squamous cell carcinoma.