According to the literature, in HPV16+/p53WT HNSCC, where wild type p53 is inactivated by the HPV oncogene, E6, high ALDH7A1 correlated with poor prognosis [29], indicating that p53 functional status is an important factor influencing the association between ALDH7A1 expression and patient prognosis. Here, TP53 is linked to head and neck squamous cell carcinoma.