ALDH7A1 and hepatocellular carcinoma: It is evident that ALDH7A1 expression significantly increased (600-fold) after heat induction at 44 °C, and Tan IIA effectively suppressed the transcriptional expression levels of ALDH7A1 in the sublethal heat-induced Huh-7 cells (Fig. 3F–H), suggesting its potential role in Tan IIA treatment for heat-induced HCC.