Tan IIA exerts its anti-tumor effects through a variety of mechanisms, including the induction of apoptosis via p53/PTPN11/SHP2 pathway, and induction of cell cycle arrest via downregulation of cyclin D1, A, and E, and suppression of metastasis via inhibition of STAT3 activation [7, 8]. This evidence concerns the gene TP53 and neoplasm.