Moreover, we also found that EMP2 is more likely to be expressed in squamous carcinoma in other organs, such as squamous skin carcinoma, squamous cervical carcinoma, etc. Our in vivo data showed that EMP2-directed ADC was highly effective in the treatment of LSCC, and further preclinical studies or early-phase clinical trials are worthwhile. This evidence concerns the gene EMP2 and squamous cell carcinoma.