Considering that the C3PO complex takes part in the RNAi pathway broadly in animal kingdom,[13, 14] we verified whether this complex, particularly Translin, affected the infection of other arboviruses in their arthropod vectors, such as sindbis virus (SINV) transmitted by mosquito Culex quinquefasciatus and severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) vectored by tick Haemaphysalis longicornis. The gene discussed is TSNAX; the disease is Fever.