C3PO inhibits miRNA production through degrading miRNA precursors with mismatched bulges in the stem region[14] while it promotes siRNA functions by assisting Ago2 to degrade the passenger strands of siRNA duplexes.[13] Although C3PO has been reported to play crucial roles in numerous biological processes in animals such as cell proliferation, maintenance of telomere‐related transcript homeostasis, hippocampal synaptic plasticity, and pathogenic vascular stiffness,[17, 18, 19, 20] whether C3PO affects viral infection in arthropod vectors through regulating RNAi molecules remains elusive. This evidence concerns the gene TSNAX and viral infectious disease.